The richly decorated portal, housed between half pilasters with composite capitals, adorned with angels and rosettes, displays the crest of the Granafei family. It is important to note one particular; the crest of the Granafei family in the 1500s was a rampant lion with three heads of wheat, but on the portal in via Lucantonio Resta, we find a bipartite crest that has, on the left-hand side, the rampant lion with three heads of wheat, and on the right, the Calvary or Latin cross. The latter indicates ecclesiastical status and, as the historian Mario Vinci notes in one if his studies, the same crest is found in the Palazzo Granafei in Brindisi. The bipartite crest can be attributed to the abbot Francesco Luca Granafei, who lived in the second half of 17th century, the brother of Duke Scipione of Serranova. It is likely therefore, that the portal was put in place a few decades after the construction of the palazzo.
The window with garland motifs on the imposts and frieze and the gargoyle with apotropaic motify are some of the few elements remaining from an important palazzo dating back to the 1500s belonging to this noble family.